CellRegenX is a combination of two naturally-derived compounds found to work synergistically and optimally at a particular ratio to induce and maintain a shift in intercellular pH towards alkaline environment.

Lithium

Lithium is known to activate the Na+/H+ exchanger by competing with Na+.¹ Both Na+ and Li+ are known to serve as transport substrates for the Na+/H+ exchanger and replacement of external NaCl with LiCl induced cytoplasmic alkalization.

In a large Japanese observational cohort, an inverse correlation between drinking water lithium concentrations and all causes of mortality in 18 neighboring Japanese municipalities with a total of 1,206,174 individuals (b = -0.661, p = 0.003) was reported.²

The daily value of Lithium for human is not established yet, but most authors agree that a healthy adult diet should include about 1-2 milligram of Lithium daily. CellRegenX contains 1 mg of lithium orotate, which could be considered as a supplementation of a normal physiological dose.

Defined lithium deficiency diseases have not been characterized in humans, but low lithium intakes from water supplies were associated with increased rates of suicides, homicides and the arrest rates for drug use and other crimes. Continuous administration of lithium leads to increased telomere length. Telomeres are protective DNA protein complexes at the ends of each chromosome, maintained primarily by the enzyme telomerase. Telomere shortening is also a hallmark of aging³, and has been associated with oxidative stress, inflammation and chronic somatic diseases.

Glycyrrhizic acid (licorice)

Licorice is known for its antiviral, antimicrobial, anti-inflammatory, laxative and hepatoprotective effects. Interestingly, licorice has been used in Ayurveda medicine for rejuvenation for many years. Licorice is also a very common ingredient in traditional Chinese medicine. Aldosterone and licorice, which has the ability to mimic effect of aldosterone in the human body, are known to promote intracellular pH alkalization.⁴⁵

CellRegenX contains 250 mg of standardized licorice root, containing approximately 5-15 mg of glycyrrhizic acid. According to scientific research and our independent studies of human volunteers taking CellRegenX up to 21 months, this amount of licorice taken daily is completely safe and does not affect hormone levels.

In Europe, 100mg of glycyrrhizic acid per day is considered to be safe and in Denmark, 200 mg a day. The United States Food & Drug Administration (FDA) has determined licorice to be a generally safe product, but warns about excessive consumption. It is also true that excessive consumption of licorice may have adverse health effects. However, CellRegenX contains glycyrrhizic acid at levels well below the limits suggested by the FDA.
 

''Licorice (or ‘liquorice’) is a plant of ancient origin and steeped in history. Licorice extracts and its principle component, glycyrrhizin, have extensive use in foods, tobacco and in both traditional and herbal medicine. As a result, there is a high level of use of licorice and glycyrrhizin in the US with an estimated consumption of 0.027–3.6 mg glycyrrhizin/kg/day. Both products have been approved for use in foods by most national and supranational regulatory agencies."

 


¹ Kobayashi Y, Pang T, Iwamoto T, Wakabayashi S, Shigekawa M. Lithium activates mammalian Na+/H+ exchangers: Isoform specificity and inhibition by genistein. Pflugers Arch Eur J Physiol. 2000;439(4):455-462. doi:10.1007/s004240050963.

² Schrauzer GN (2002) Lithium: occurrence, dietary intakes, nutritional essentiality. J Am Coll Nutr 21:14–21.

³ Wei Y Bin, Backlund L, Wegener G, Mathé AA, Lavebratt C. Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium. Int J Neuropsychopharmacol. 2015;18(7):pyv002. doi:10.1093/ijnp/pyv002.

⁴ San-E Ishikawa and T Saito The effect of glycyrrhetinic acid on the action of aldosterone in stimulating sodium transport in frog skin Endocrinologia japonica 27(6):697-701 · January 1981 DOI: 10.1507/endocrj1954.27.697.

⁵ Cruz-Vega D, Verde-Star MJ, Salinas-Gonzalez NR, et al. Review of pharmacological effects of Glycyrrhiza radix and its bioactive compounds. Zhongguo Zhong Yao Za Zhi. 2009;22(April 2008):557-559. doi:10.1002/ptr.